Plasma lipoprotein particle clearance

Across TCGA cell cohorts, RNA activity of the Plasma lipoprotein particle clearance pathway is significantly associated with the RNA expression of multiple genes, with the BREAST cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are REXO2, TTC27, and TMED3, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, REXO2 grouped by Plasma lipoprotein particle clearance-low versus -high activity in BREAST.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BREAST	REXO2 →	-0.824	-0.905	.003	<.001	3	5
LUNG_SCLC	TTC27 →	-0.989	-0.996	<.001	.007	3	4
LUNG_SCLC	TMED3 →	-0.884	-0.719	.003	.004	3	4
LARGE_INTESTINE	ISCU →	-0.464	-0.826	.003	.004	3	4
BLOOD_Leukemia	GAS2L1 →	-1.791	-0.784	.002	.009	3	4
OESOPHAGUS	GRIP1 →	+1.859	+1.142	.002	.004	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

REXO2 by Plasma lipoprotein particle clearance activity — BREAST

Explore this box plot interactively →