Plasma lipoprotein particle clearance

Across TCGA cell cohorts, RNA activity of the Plasma lipoprotein particle clearance pathway is significantly associated with the shRNA dependency of multiple genes, with the BLOOD_Myeloma cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are UNC5C, CARF, and KIF6, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, UNC5C grouped by Plasma lipoprotein particle clearance-low versus -high activity in BLOOD_Myeloma.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Myeloma	UNC5C →	+0.376	+0.134	.005	.001	3	5
STOMACH	CARF →	+0.207	+0.195	.002	.003	3	5
SKIN	KIF6 →	-0.157	-0.141	.001	.001	3	5
UPPER_AERODIGESTIVE_TRACT	OTX1 →	-0.126	-0.140	.003	<.001	3	5
KIDNEY	ATP5MC2 →	-0.239	-0.119	<.001	.002	3	4
BLOOD_Myeloma	NOTCH3 →	-0.272	-0.144	.007	.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

UNC5C by Plasma lipoprotein particle clearance activity — BLOOD_Myeloma

Explore this box plot interactively →