Plasma lipoprotein particle clearance

Across TCGA cell cohorts, RNA activity of the Plasma lipoprotein particle clearance pathway is significantly associated with the RNA expression of multiple genes, with the BONE cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are PLAU, SOCS3, and NCEH1, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Plasma lipoprotein particle clearance activity versus PLAU in BONE (Pearson r = 0.76).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BONE	PLAU →	+4.740	+1.704	<.001	.001	3	4
KIDNEY	SOCS3 →	+0.896	+0.233	.002	.005	3	4
BONE	NCEH1 →	+2.852	+1.820	<.001	<.001	3	4
LUNG_SCLC	PXDC1 →	+2.594	+1.108	<.001	.001	3	4
BONE	IKBIP →	+1.199	+1.938	.003	<.001	3	4
BONE	FOSL1 →	+4.281	+1.610	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0034381 vs PLAU — BONE

Explore this scatter interactively →