Very-low-density lipoprotein particle assembly

Across TCGA patient cohorts, RNA activity of the Very-low-density lipoprotein particle assembly pathway is significantly associated with the protein abundance of multiple proteins, with the HNSC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are LPCAT3, CD9, and MALT1, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Very-low-density lipoprotein particle assembly activity versus LPCAT3 in HNSC (Pearson r = 0.34).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
HNSC	LPCAT3 →	+0.506	+0.078	<.001	.006	3	6
HNSC	CD9 →	+0.685	+0.083	.001	.002	3	5
GBM	MALT1 →	+0.231	+0.040	.007	.005	2	5
COAD	NARS1 →	+0.293	+0.048	<.001	<.001	3	4
COAD	MAP4_S853 →	-0.259	-0.047	.003	<.001	3	4
OV	KATNIP_S660 →	+0.554	+0.053	.007	.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0034379 vs LPCAT3 — HNSC

Explore this scatter interactively →