Very-low-density lipoprotein particle assembly

Across TCGA pan-cancer cohorts, RNA activity of the Very-low-density lipoprotein particle assembly pathway is associated with patient survival in 17 of 34 cancer lineages. Pathway activity is summarized from the expression of its 12 member genes.

The strongest signal is observed in sarcoma (SARC), where higher Very-low-density lipoprotein particle assembly pathway activity is associated with poorer overall survival. In most high-consensus cancer types, elevated pathway activity shows an unfavorable survival association, although some cancer types, such as READ and COAD, show the opposite pattern, with higher activity associated with better survival.

SARC, UVM, and LGG are the cancer lineages in which this pathway most reproducibly stratifies patient survival.

Pathway-activity survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 represent the survival AUCs for the high- and low-pathway-activity groups, respectively. The group with the lower AUC is interpreted as having poorer survival. The reported p-values are derived from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
SARC	OS	Median	All	0.411	0.587	.001	43	view →
UVM	OS	Tertile	III,IV	0.373	0.935	.004	40	view →
LGG	OS	Tertile	All	0.751	0.862	.003	33	view →
MESO	OS	Quartile	All	0.143	0.622	.026	24	view →
READ	DFS	Quartile	II,III,IV	0.936	0.727	.002	21	view →
HNSC	OS	Median	II,III,IV	0.632	0.770	.020	13	view →
LIHC	OS	Median	II,III,IV	0.246	0.565	.013	10	view →
COAD	DFS	Quartile	IV	0.683	0.227	.001	6	view →
UCS	OS	Median	IV	0.735	0.320	.035	6	view →
LAML	DFS	Median	All	0.259	0.514	.048	4	view →
GBM	OS	Median	All	0.239	0.415	.029	3	view →
BLCA	OS	Quartile	IV	0.549	0.280	.019	3	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 17 lineages.

GO:0034379–SARC (OS)

Open the SARC breakdown →