Very-low-density lipoprotein particle assembly

Across TCGA patient cohorts, RNA activity of the Very-low-density lipoprotein particle assembly pathway is significantly associated with the RNA expression of multiple genes, with the PDAC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are FBXO3, DTD1, and SEPTIN10, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Very-low-density lipoprotein particle assembly activity versus FBXO3 in PDAC (Pearson r = -0.28).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PDAC	FBXO3 →	-0.241	-0.213	.006	.001	3	4
GBM	DTD1 →	-0.263	-0.106	<.001	<.001	3	4
CCRCC	SEPTIN10 →	-0.304	-0.180	.007	.001	3	4
GBM	CCDC7 →	-0.406	-0.079	<.001	.006	3	4
GBM	SOD2 →	+1.165	+0.145	<.001	<.001	3	4
LSCC	IL15RA →	+0.319	+0.105	.008	.008	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0034379 vs FBXO3 — PDAC

Explore this scatter interactively →