Very-low-density lipoprotein particle assembly

Across TCGA cell cohorts, RNA activity of the Very-low-density lipoprotein particle assembly pathway is significantly associated with the RNA expression of multiple genes, with the BREAST cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are LRRC3, NCBP2, and SAPCD2, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Very-low-density lipoprotein particle assembly activity versus LRRC3 in BREAST (Pearson r = -0.49).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BREAST	LRRC3 →	-1.708	-1.170	.005	.004	3	4
BLOOD_Myeloma	NCBP2 →	-0.765	-0.553	.001	.006	3	4
LIVER	SAPCD2 →	+2.250	+1.154	.001	.009	2	4
KIDNEY	DLL3 →	-0.826	-1.466	<.001	<.001	3	3
OESOPHAGUS	PILRB →	+1.498	+0.813	<.001	.002	3	3
BREAST	FBXO24 →	-0.546	-1.265	<.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0034379 vs LRRC3 — BREAST

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