High-density lipoprotein particle remodeling

Across TCGA patient cohorts, RNA activity of the High-density lipoprotein particle remodeling pathway is significantly associated with the protein abundance of multiple proteins, with the GBM cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are DCHS1, CHAF1A, and FANCD2_S1435, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, High-density lipoprotein particle remodeling activity versus DCHS1 in GBM (Pearson r = -0.40).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	DCHS1 →	-0.346	-0.071	<.001	<.001	3	4
UCEC	CHAF1A →	+0.416	+0.063	<.001	.002	3	4
LSCC	FANCD2_S1435 →	+0.828	+0.045	<.001	<.001	3	4
UCEC	FKBP7 →	-0.453	-0.059	<.001	<.001	3	4
PDAC	TMSB10_T34 →	-0.728	-0.062	.001	.002	3	3
PDAC	TOP3A_S971 →	+0.719	+0.088	<.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0034375 vs DCHS1 — GBM

Explore this scatter interactively →