High-density lipoprotein particle remodeling

Across TCGA pan-cancer cohorts, RNA activity of the High-density lipoprotein particle remodeling pathway is associated with patient survival in 21 of 34 cancer lineages. Pathway activity is summarized from the expression of its 16 member genes.

The strongest signal is observed in mesothelioma (MESO), where higher High-density lipoprotein particle remodeling pathway activity is associated with better disease-free survival. In most high-consensus cancer types, elevated pathway activity shows an unfavorable survival association, although some cancer types, such as MESO and LGG, show the opposite pattern, with higher activity associated with better survival.

MESO, LGG, and UCS are the cancer lineages in which this pathway most reproducibly stratifies patient survival.

Pathway-activity survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 represent the survival AUCs for the high- and low-pathway-activity groups, respectively. The group with the lower AUC is interpreted as having poorer survival. The reported p-values are derived from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
MESO	DFS	Tertile	All	0.530	0.282	.001	82	view →
LGG	DFS	Median	All	0.812	0.665	<.001	49	view →
UCS	OS	Median	All	0.514	0.777	.007	38	view →
LIHC	OS	Quartile	All	0.858	0.647	.002	38	view →
ACC	DFS	Median	II,III,IV	0.187	0.714	.003	30	view →
SCLC	DFS	Quartile	All	0.811	0.491	.006	18	view →
LUSC	DFS	Median	III,IV	0.624	0.341	.007	16	view →
KIRP	DFS	Tertile	II,III,IV	1.000	0.321	.007	12	view →
THCA	DFS	Tertile	III,IV	0.862	0.249	.019	9	view →
READ	OS	Quartile	III,IV	0.597	1.000	.007	8	view →
THYM	OS	Median	II,III,IV	0.700	0.979	.006	7	view →
DLBC	DFS	Median	III,IV	1.000	0.146	.017	6	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 21 lineages.

GO:0034375–MESO (DFS)

Open the MESO breakdown →