High-density lipoprotein particle remodeling

Across TCGA patient cohorts, RNA activity of the High-density lipoprotein particle remodeling pathway is significantly associated with the RNA expression of multiple genes, with the GBM cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are MMP19, SLC2A3, and SYDE1, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, High-density lipoprotein particle remodeling activity versus MMP19 in GBM (Pearson r = 0.46).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	MMP19 →	+0.918	+0.144	<.001	<.001	3	7
COAD	SLC2A3 →	+1.112	+0.184	.001	.001	3	7
OV	SYDE1 →	+1.318	+0.171	<.001	.001	3	6
OV	PCOLCE →	+0.970	+0.127	<.001	.005	3	6
GBM	SERPINE1 →	+1.211	+0.133	<.001	<.001	3	6
GBM	LOX →	+1.619	+0.159	<.001	<.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0034375 vs MMP19 — GBM

Explore this scatter interactively →