High-density lipoprotein particle remodeling

Across TCGA cell cohorts, RNA activity of the High-density lipoprotein particle remodeling pathway is significantly associated with the RNA expression of multiple genes, with the KIDNEY cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are CEBPZ, AKIP1, and AKR7A2, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, CEBPZ grouped by High-density lipoprotein particle remodeling-low versus -high activity in KIDNEY.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
KIDNEY	CEBPZ →	+0.455	+1.606	<.001	<.001	3	5
UPPER_AERODIGESTIVE_TRACT	AKIP1 →	-1.133	-0.675	.005	.001	3	4
UPPER_AERODIGESTIVE_TRACT	AKR7A2 →	-0.668	-0.909	.008	.003	3	4
SOFT_TISSUE	CCDC40 →	-1.155	-1.656	.004	.002	3	4
SOFT_TISSUE	AP2A2 →	-0.765	-1.518	<.001	.001	3	4
CNS	FBXO3 →	-0.546	-1.158	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

CEBPZ by High-density lipoprotein particle remodeling activity — KIDNEY

Explore this box plot interactively →