High-density lipoprotein particle remodeling

Across TCGA cell cohorts, RNA activity of the High-density lipoprotein particle remodeling pathway is significantly associated with the RNA expression of multiple genes, with the UPPER_AERODIGESTIVE_TRACT cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are HSD17B6, DAPK2, and DLG5, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, High-density lipoprotein particle remodeling activity versus HSD17B6 in UPPER_AERODIGESTIVE_TRACT (Pearson r = -0.73).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UPPER_AERODIGESTIVE_TRACT	HSD17B6 →	-1.195	-1.441	.005	<.001	3	3
UPPER_AERODIGESTIVE_TRACT	DAPK2 →	-1.393	-1.386	<.001	<.001	3	3
LARGE_INTESTINE	DLG5 →	-1.141	-1.124	<.001	.007	3	3
LARGE_INTESTINE	METTL23 →	-0.497	-0.706	.001	.005	3	3
SOFT_TISSUE	RBAK →	+0.893	+1.127	.003	.009	3	3
BONE	HOXB3 →	-1.503	-1.542	.002	.001	2	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0034375 vs HSD17B6 — UPPER_AERODIGESTIVE_TRACT

Explore this scatter interactively →