Triglyceride-rich lipoprotein particle remodeling

Across TCGA patient cohorts, RNA activity of the Triglyceride-rich lipoprotein particle remodeling pathway is significantly associated with the protein abundance of multiple proteins, with the BRCA cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are CPD, TLN2, and TMOD2, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Triglyceride-rich lipoprotein particle remodeling activity versus CPD in BRCA (Pearson r = -0.32).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	CPD →	-0.534	-0.097	<.001	<.001	3	6
BRCA	TLN2 →	+0.549	+0.081	<.001	.002	3	5
BRCA	TMOD2 →	+0.553	+0.109	<.001	<.001	3	5
BRCA	CD36 →	+0.885	+0.074	<.001	<.001	3	5
BRCA	COL6A6 →	+0.465	+0.056	.001	.003	3	5
BRCA	CWC22_S28 →	-0.720	-0.137	.004	.003	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0034370 vs CPD — BRCA

Explore this scatter interactively →