Triglyceride-rich lipoprotein particle remodeling

Across TCGA pan-cancer cohorts, RNA activity of the Triglyceride-rich lipoprotein particle remodeling pathway is associated with patient survival in 23 of 34 cancer lineages. Pathway activity is summarized from the expression of its 12 member genes.

The strongest signal is observed in uterine carcinosarcoma (UCS), where higher Triglyceride-rich lipoprotein particle remodeling pathway activity is associated with poorer overall survival. In most high-consensus cancer types, elevated pathway activity shows an unfavorable survival association, although some cancer types, such as LGG and THCA, show the opposite pattern, with higher activity associated with better survival.

UCS, ACC, and HNSC are the cancer lineages in which this pathway most reproducibly stratifies patient survival.

Pathway-activity survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 represent the survival AUCs for the high- and low-pathway-activity groups, respectively. The group with the lower AUC is interpreted as having poorer survival. The reported p-values are derived from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
UCS	OS	Quartile	III,IV	0.183	0.686	<.001	104	view →
ACC	DFS	Tertile	All	0.144	0.588	<.001	67	view →
HNSC	OS	Median	All	0.611	0.788	<.001	60	view →
LGG	DFS	Median	All	0.486	0.316	<.001	54	view →
LUSC	DFS	Tertile	All	0.326	0.495	.010	50	view →
THCA	DFS	Median	All	0.880	0.783	.001	47	view →
LIHC	OS	Median	All	0.748	0.421	<.001	46	view →
LUAD	OS	Quartile	II,III,IV	0.717	0.355	<.001	44	view →
KIRC	OS	Median	All	0.688	0.575	.004	36	view →
CHOL	OS	Median	II,III,IV	0.274	0.795	.004	28	view →
COAD	DFS	Quartile	II,III,IV	0.257	0.708	<.001	24	view →
MESO	DFS	Tertile	III,IV	0.457	0.266	.014	18	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 23 lineages.

GO:0034370–UCS (OS)

Open the UCS breakdown →