Triglyceride-rich lipoprotein particle remodeling

Across TCGA cell cohorts, RNA activity of the Triglyceride-rich lipoprotein particle remodeling pathway is significantly associated with the RNA expression of multiple genes, with the CNS cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are GTPBP4, MYDGF, and SLC22A4, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, GTPBP4 grouped by Triglyceride-rich lipoprotein particle remodeling-low versus -high activity in CNS.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CNS	GTPBP4 →	+0.609	+1.026	.001	.001	3	4
BLOOD_Leukemia	MYDGF →	+0.792	+0.985	.008	.009	3	4
BLOOD_Myeloma	SLC22A4 →	-0.482	-1.678	.004	<.001	3	4
KIDNEY	COX6B1 →	-0.445	-1.028	.004	.004	3	4
SOFT_TISSUE	NBAS →	-0.721	-1.585	.003	<.001	3	3
SOFT_TISSUE	APEX2 →	+0.487	+1.299	.002	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GTPBP4 by Triglyceride-rich lipoprotein particle remodeling activity — CNS

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