Triglyceride-rich lipoprotein particle remodeling

Across TCGA cell cohorts, RNA activity of the Triglyceride-rich lipoprotein particle remodeling pathway is significantly associated with the RNA expression of multiple genes, with the BLOOD_Leukemia cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are APOE, LCAT, and APOC1, each associated with the pathway in up to 18 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Triglyceride-rich lipoprotein particle remodeling activity versus APOE in BLOOD_Leukemia (Pearson r = 0.51).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	APOE →	+5.197	+1.243	<.001	<.001	3	18
OESOPHAGUS	LCAT →	+1.562	+1.335	<.001	.001	3	11
BLOOD_Leukemia	APOC1 →	+3.801	+0.875	<.001	<.001	3	9
OESOPHAGUS	SLC12A4 →	+1.707	+1.555	.003	.001	2	9
SKIN	C19orf12 →	+0.990	+1.043	.001	<.001	3	8
PANCREAS	KIRREL2 →	+0.859	+1.115	.003	.001	3	8

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0034370 vs APOE — BLOOD_Leukemia

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