Protein-containing complex remodeling

Across TCGA patient cohorts, RNA activity of the Protein-containing complex remodeling pathway is significantly associated with the protein abundance of multiple proteins, with the GBM cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are CLINT1, COMMD4, and JPT1_S87, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Protein-containing complex remodeling activity versus CLINT1 in GBM (Pearson r = 0.22).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	CLINT1 →	+0.132	+0.061	<.001	<.001	3	5
GBM	COMMD4 →	+0.149	+0.059	.009	<.001	3	5
GBM	JPT1_S87 →	-0.478	-0.068	.001	<.001	3	5
GBM	RRP9 →	-0.328	-0.060	<.001	.002	3	4
GBM	ATAD2_S342 →	-0.778	-0.066	<.001	<.001	3	4
BRCA	SMC2 →	-0.379	-0.023	.002	.005	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0034367 vs CLINT1 — GBM

Explore this scatter interactively →