Protein-containing complex remodeling

Across TCGA patient cohorts, RNA activity of the Protein-containing complex remodeling pathway is significantly associated with the RNA expression of multiple genes, with the OV cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are MMP19, PLA2G2A, and AKAP12, each associated with the pathway in up to 9 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Protein-containing complex remodeling activity versus MMP19 in OV (Pearson r = 0.42).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OV	MMP19 →	+1.112	+0.227	<.001	<.001	3	9
OV	PLA2G2A →	+1.996	+0.202	.001	<.001	3	7
OV	AKAP12 →	+1.394	+0.163	.002	.003	3	7
COAD	FLT1 →	+0.787	+0.228	<.001	<.001	3	7
GBM	MEDAG →	+1.006	+0.174	<.001	<.001	3	7
COAD	SERPINE1 →	+1.563	+0.209	<.001	.002	3	7

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0034367 vs MMP19 — OV

Explore this scatter interactively →