Protein-containing complex remodeling

Across TCGA cell cohorts, RNA activity of the Protein-containing complex remodeling pathway is significantly associated with the RNA expression of multiple genes, with the OESOPHAGUS cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are DDX18, ATP6AP2, and TPGS1, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, DDX18 grouped by Protein-containing complex remodeling-low versus -high activity in OESOPHAGUS.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OESOPHAGUS	DDX18 →	+0.747	+0.789	<.001	.005	3	5
OVARY	ATP6AP2 →	-0.835	-1.049	<.001	.009	1	7
LUNG_NSCLC_LUSC	TPGS1 →	-1.091	-1.630	.006	<.001	3	5
PANCREAS	TNFSF10 →	-1.717	-1.141	.006	.004	2	5
PANCREAS	KCMF1 →	+0.634	+1.176	<.001	<.001	3	4
UPPER_AERODIGESTIVE_TRACT	NINJ1 →	-1.488	-0.398	.003	.008	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

DDX18 by Protein-containing complex remodeling activity — OESOPHAGUS

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