Protein-containing complex remodeling

Across TCGA cell cohorts, RNA activity of the Protein-containing complex remodeling pathway is significantly associated with the RNA expression of multiple genes, with the SOFT_TISSUE cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are TSPAN5, ZFPM2, and DCBLD2, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Protein-containing complex remodeling activity versus TSPAN5 in SOFT_TISSUE (Pearson r = -0.62).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SOFT_TISSUE	TSPAN5 →	-2.778	-1.331	.008	.003	3	4
SOFT_TISSUE	ZFPM2 →	-1.355	-1.665	.008	.002	3	4
SOFT_TISSUE	DCBLD2 →	-4.823	-1.336	<.001	.003	3	4
PANCREAS	MRPS2 →	+0.871	+1.082	.003	.001	3	4
BONE	SLC31A1 →	+0.874	+0.982	.006	.006	3	4
LUNG_NSCLC_LUAD	PDP1 →	-1.339	-1.123	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0034367 vs TSPAN5 — SOFT_TISSUE

Explore this scatter interactively →