Response to type I interferon

Across TCGA cell cohorts, RNA activity of the Response to type I interferon pathway is significantly associated with the RNA expression of multiple genes, with the STOMACH cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are PLPBP, PCOLCE2, and METTL21A, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Response to type I interferon activity versus PLPBP in STOMACH (Pearson r = 0.64).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
STOMACH	PLPBP →	+1.139	+0.324	.001	.006	3	6
PANCREAS	PCOLCE2 →	+1.161	+0.287	.008	.001	3	5
UPPER_AERODIGESTIVE_TRACT	METTL21A →	+1.004	+0.472	<.001	.002	3	5
SOFT_TISSUE	ATP5F1D →	+0.745	+0.465	.005	.005	3	4
BLOOD_Myeloma	VAT1 →	+1.228	+0.197	.009	.001	3	4
URINARY_TRACT	LNPK →	+0.863	+0.680	.001	.003	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0034340 vs PLPBP — STOMACH

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