Response to type I interferon

Across TCGA pan-cancer cohorts, RNA activity of the Response to type I interferon pathway is associated with patient survival in 25 of 34 cancer lineages. Pathway activity is summarized from the expression of its 89 member genes.

The strongest signal is observed in skin cutaneous melanoma (SKCM), where higher Response to type I interferon pathway activity is associated with better overall survival. In most high-consensus cancer types, elevated pathway activity shows an unfavorable survival association, although some cancer types, such as SKCM and HNSC, show the opposite pattern, with higher activity associated with better survival.

SKCM, HNSC, and BRCA are the cancer lineages in which this pathway most reproducibly stratifies patient survival.

Pathway-activity survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 represent the survival AUCs for the high- and low-pathway-activity groups, respectively. The group with the lower AUC is interpreted as having poorer survival. The reported p-values are derived from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
SKCM	OS	Median	All	0.844	0.728	<.001	96	view →
HNSC	DFS	Median	IV	0.472	0.237	<.001	96	view →
BRCA	OS	Median	All	0.950	0.901	.002	83	view →
KIRC	DFS	Quartile	II,III,IV	0.347	0.707	<.001	70	view →
UVM	DFS	Median	All	0.311	0.653	<.001	64	view →
LGG	OS	Median	All	0.726	0.880	<.001	50	view →
KIRP	DFS	Tertile	All	0.494	0.811	.001	38	view →
ESCA	DFS	Tertile	III,IV	0.504	0.211	<.001	36	view →
LAML	DFS	Quartile	All	0.284	0.698	.001	30	view →
CESC	OS	Tertile	II,III,IV	0.903	0.681	.007	26	view →
SARC	OS	Median	All	0.916	0.780	<.001	26	view →
UCEC	DFS	Tertile	All	0.538	0.683	.001	26	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 25 lineages.

GO:0034340–SKCM (OS)

Open the SKCM breakdown →