Adherens junction organization

Across TCGA patient cohorts, RNA activity of the Adherens junction organization pathway is significantly associated with the RNA expression of multiple genes, with the LSCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are FGF1, PLAT, and PPFIA2, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Adherens junction organization activity versus FGF1 in LSCC (Pearson r = 0.06).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	FGF1 →	+0.988	+0.296	<.001	<.001	3	6
LSCC	PLAT →	+1.336	+0.164	<.001	.001	3	5
PDAC	PPFIA2 →	+0.493	+0.166	<.001	<.001	3	5
BRCA	LINC00702 →	+0.623	+0.293	<.001	<.001	3	5
BRCA	GALNT5 →	+1.626	+0.260	<.001	.001	3	5
LSCC	SUGCT →	+1.125	+0.287	.003	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0034332 vs FGF1 — LSCC

Explore this scatter interactively →