Adherens junction organization

Across TCGA pan-cancer cohorts, RNA activity of the Adherens junction organization pathway is associated with patient survival in 20 of 34 cancer lineages. Pathway activity is summarized from the expression of its 57 member genes.

The strongest signal is observed in kidney renal papillary cell carcinoma (KIRP), where higher Adherens junction organization pathway activity is associated with poorer disease-free survival. In most high-consensus cancer types, elevated pathway activity shows an unfavorable survival association, although some cancer types, such as SCLC and UVM, show the opposite pattern, with higher activity associated with better survival.

KIRP, SCLC, and MESO are the cancer lineages in which this pathway most reproducibly stratifies patient survival.

Pathway-activity survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 represent the survival AUCs for the high- and low-pathway-activity groups, respectively. The group with the lower AUC is interpreted as having poorer survival. The reported p-values are derived from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
KIRP	DFS	Tertile	All	0.571	0.746	.002	66	view →
SCLC	OS	Median	All	0.506	0.140	<.001	62	view →
MESO	OS	Tertile	All	0.286	0.530	.001	61	view →
ACC	DFS	Median	All	0.448	0.703	.003	44	view →
LGG	DFS	Quartile	All	0.590	0.775	<.001	42	view →
UVM	OS	Median	II,III,IV	0.799	0.475	.013	38	view →
LUSC	OS	Quartile	III,IV	0.392	0.709	.013	24	view →
UCEC	OS	Tertile	III,IV	0.298	0.660	.020	22	view →
KICH	OS	Median	III,IV	0.581	0.947	.010	22	view →
HNSC	DFS	Tertile	IV	0.752	0.560	.001	18	view →
LUAD	OS	Quartile	II,III,IV	0.931	0.692	.020	16	view →
LIHC	DFS	Median	All	0.179	0.362	.007	13	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 20 lineages.

GO:0034332–KIRP (DFS)

Open the KIRP breakdown →