Primary alcohol catabolic process

Across TCGA patient cohorts, RNA activity of the Primary alcohol catabolic process pathway is significantly associated with the protein abundance of multiple proteins, with the LUAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are AKR1B10, AKR1C3, and LDHD, each associated with the pathway in up to 8 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Primary alcohol catabolic process activity versus AKR1B10 in LUAD (Pearson r = 0.49).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUAD	AKR1B10 →	+2.046	+0.104	<.001	<.001	3	8
LSCC	AKR1C3 →	+1.140	+0.085	<.001	<.001	3	8
UCEC	LDHD →	+0.574	+0.096	<.001	<.001	3	7
CCRCC	BIN3 →	+0.357	+0.094	<.001	<.001	3	7
GBM	DAXX →	-0.326	-0.088	.001	.002	3	7
LSCC	CBR1 →	+0.695	+0.071	<.001	.002	3	7

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0034310 vs AKR1B10 — LUAD

Explore this scatter interactively →