Primary alcohol catabolic process

Across TCGA patient cohorts, RNA activity of the Primary alcohol catabolic process pathway is significantly associated with the RNA expression of multiple genes, with the UCEC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are AKR1C1, ALDH3B1, and SULT1A1, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Primary alcohol catabolic process activity versus AKR1C1 in UCEC (Pearson r = 0.22).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	AKR1C1 →	+1.602	+0.167	.001	.005	3	6
UCEC	ALDH3B1 →	+0.959	+0.237	<.001	<.001	3	6
CCRCC	SULT1A1 →	+0.677	+0.151	<.001	<.001	3	5
UCEC	AKR1C2 →	+2.254	+0.209	<.001	<.001	3	5
UCEC	AKR1C3 →	+2.279	+0.200	<.001	<.001	3	5
BRCA	HAUS5 →	-0.438	-0.169	.005	.004	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0034310 vs AKR1C1 — UCEC

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