Primary alcohol catabolic process

Across TCGA cell cohorts, RNA activity of the Primary alcohol catabolic process pathway is significantly associated with the RNA expression of multiple genes, with the LUNG_NSCLC_LUAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ALDH2, PBX2, and VPS18, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Primary alcohol catabolic process activity versus ALDH2 in LUNG_NSCLC_LUAD (Pearson r = 0.61).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUAD	ALDH2 →	+3.056	+1.214	<.001	<.001	3	5
OVARY	PBX2 →	-0.747	-0.227	.002	.007	3	4
STOMACH	VPS18 →	-0.980	-0.364	<.001	.001	3	4
STOMACH	FOXM1 →	-0.999	-0.317	.002	.008	3	4
STOMACH	PHF13 →	-0.991	-0.409	.001	.007	3	4
STOMACH	ASB8 →	-0.821	-0.338	<.001	.004	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0034310 vs ALDH2 — LUNG_NSCLC_LUAD

Explore this scatter interactively →