Primary alcohol metabolic process

Across TCGA patient cohorts, RNA activity of the Primary alcohol metabolic process pathway is significantly associated with the protein abundance of multiple proteins, with the LUAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are WDR75, SYNCRIP, and DAXX, each associated with the pathway in up to 9 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Primary alcohol metabolic process activity versus WDR75 in LUAD (Pearson r = -0.36).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUAD	WDR75 →	-0.307	-0.047	<.001	<.001	3	8
GBM	SYNCRIP →	-0.300	-0.034	<.001	<.001	3	8
LSCC	DAXX →	-0.216	-0.038	.005	<.001	2	9
BRCA	ARHGEF37 →	+0.464	+0.025	<.001	.001	3	8
GBM	UTP3 →	-0.393	-0.032	<.001	.001	3	7
BRCA	UTP4 →	-0.314	-0.021	<.001	.002	3	7

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0034308 vs WDR75 — LUAD

Explore this scatter interactively →