Toll-like receptor 9 signaling pathway

Across TCGA patient cohorts, RNA activity of the Toll-like receptor 9 signaling pathway pathway is significantly associated with the RNA expression of multiple genes, with the BRCA cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are MYO5C, TNFSF13B, and MKNK2, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Toll-like receptor 9 signaling pathway activity versus MYO5C in BRCA (Pearson r = -0.07).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	MYO5C →	-0.780	-0.625	.005	.002	3	4
LSCC	TNFSF13B →	+0.482	+0.684	<.001	<.001	3	4
GBM	MKNK2 →	-0.580	-0.897	<.001	.001	3	4
BRCA	DLST →	-0.239	-0.532	.002	<.001	3	4
BRCA	ZNF446 →	-0.474	-0.560	.008	.006	3	4
BRCA	SUPT16H →	-0.429	-0.603	.001	.004	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0034162 vs MYO5C — BRCA

Explore this scatter interactively →