Toll-like receptor 9 signaling pathway

Across TCGA cell cohorts, RNA activity of the Toll-like receptor 9 signaling pathway pathway is significantly associated with the RNA expression of multiple genes, with the SKIN cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are STAT3, SLC35B4, and ZNF528, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, STAT3 grouped by Toll-like receptor 9 signaling pathway-low versus -high activity in SKIN.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKIN	STAT3 →	-0.574	-0.813	<.001	<.001	3	4
SOFT_TISSUE	SLC35B4 →	+0.538	+0.875	.001	.008	3	4
BREAST	ZNF528 →	-1.626	-1.027	.001	<.001	3	4
LUNG_NSCLC_LUSC	TXNL4A →	+1.426	+1.534	.002	.003	3	4
LUNG_NSCLC_LUSC	ZNF182 →	+1.013	+1.423	.001	.001	3	4
LUNG_NSCLC_LUSC	RBM7 →	+1.074	+1.227	.003	.007	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

STAT3 by Toll-like receptor 9 signaling pathway activity — SKIN

Explore this box plot interactively →