Regulation of toll-like receptor 2 signaling pathway

Across TCGA cell cohorts, RNA activity of the Regulation of toll-like receptor 2 signaling pathway pathway is significantly associated with the RNA expression of multiple genes, with the UPPER_AERODIGESTIVE_TRACT cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are TADA1, RAB11A, and BCL7A, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of toll-like receptor 2 signaling pathway activity versus TADA1 in UPPER_AERODIGESTIVE_TRACT (Pearson r = 0.67).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UPPER_AERODIGESTIVE_TRACT	TADA1 →	+1.059	+0.257	<.001	.002	3	5
UPPER_AERODIGESTIVE_TRACT	RAB11A →	+0.898	+0.257	.002	.002	3	4
BLOOD_Lymphoma	BCL7A →	+2.682	+0.099	.001	.007	3	4
BREAST	AKAP11 →	+0.867	+0.257	.003	.002	3	4
BREAST	SUPT16H →	+1.383	+0.399	.005	.003	3	4
PANCREAS	HERC2 →	+0.903	+0.254	.001	.004	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0034135 vs TADA1 — UPPER_AERODIGESTIVE_TRACT

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