Membrane protein proteolysis

Across TCGA cell cohorts, RNA activity of the Membrane protein proteolysis pathway is significantly associated with the shRNA dependency of multiple genes, with the STOMACH cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are TLN1, CYP2A7, and LZIC, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, TLN1 grouped by Membrane protein proteolysis-low versus -high activity in STOMACH.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
STOMACH	TLN1 →	+0.336	+0.101	.008	.006	3	5
BLOOD_Myeloma	CYP2A7 →	+0.214	+0.058	.008	.002	2	5
SKIN	LZIC →	+0.238	+0.113	<.001	<.001	3	4
OVARY	FERMT2 →	+0.392	+0.116	<.001	.005	3	4
URINARY_TRACT	CDK10 →	+0.215	+0.161	.004	.004	3	4
STOMACH	ACLY →	-0.305	-0.095	.006	.004	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

TLN1 by Membrane protein proteolysis activity — STOMACH

Explore this box plot interactively →