Positive regulation of catecholamine secretion

Across TCGA cell cohorts, RNA activity of the Positive regulation of catecholamine secretion pathway is significantly associated with the RNA expression of multiple genes, with the LIVER cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are EAF2, CRIM1, and TADA3, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, EAF2 grouped by Positive regulation of catecholamine secretion-low versus -high activity in LIVER.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LIVER	EAF2 →	+1.260	+1.627	.001	<.001	3	4
PANCREAS	CRIM1 →	-0.919	-1.105	.007	.003	2	5
LUNG_NSCLC_LUSC	TADA3 →	-1.366	-0.539	<.001	.001	3	4
LUNG_NSCLC_LUSC	EPB41L2 →	-1.973	-0.641	.004	.002	3	4
BONE	GALNT18 →	-2.795	-1.497	<.001	.008	3	4
BONE	TLR4 →	-3.187	-1.133	.001	.005	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

EAF2 by Positive regulation of catecholamine secretion activity — LIVER

Explore this box plot interactively →