Positive regulation of dopamine secretion

Across TCGA patient cohorts, RNA activity of the Positive regulation of dopamine secretion pathway is significantly associated with the RNA expression of multiple genes, with the GBM cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are SYT1, OPN4, and SHISAL1, each associated with the pathway in up to 3 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Positive regulation of dopamine secretion activity versus SYT1 in GBM (Pearson r = 0.46).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	SYT1 →	+1.658	+0.710	<.001	.005	3	3
GBM	OPN4 →	+0.258	+0.740	<.001	.003	3	2
GBM	SHISAL1 →	+1.063	+0.757	<.001	<.001	3	2
GBM	EIF2AP4 →	+0.344	+0.684	<.001	<.001	3	2
LSCC	RAB11FIP5 →	+0.960	+0.171	.001	.009	3	2
GBM	SLC45A3 →	+0.920	+0.763	<.001	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0033603 vs SYT1 — GBM

Explore this scatter interactively →