Positive regulation of dopamine secretion

Across TCGA pan-cancer cohorts, RNA activity of the Positive regulation of dopamine secretion pathway differs between tumor and matched normal tissue in 16 of the 18 cancer types tested.

The strongest signal is observed in thyroid carcinoma (THCA), where pathway activity is lower in tumor tissue than in matched normal tissue. In most cancer types, this pathway shows higher activity in tumors, although a few cancer types, such as THCA and COAD, show the opposite pattern, with lower activity in tumor tissue.

THCA, COAD, and STAD show the most reproducible tumor–normal differences in pathway activity.

Tumor vs normal pathway activity by lineage

Ranked by sampling consensus. Activity change represents the tumor-versus-normal difference in pathway activity on a log₂ scale. Positive values indicate higher pathway activity in tumor tissue. The reported p-values are derived from the corresponding differential activity tests.

Lineage	Gender	Stage	Activity change	p	Sampling consensus
THCA	All	III,IV	−0.179	<.001	11	view →
COAD	Female	II,III,IV	−0.092	<.001	10	view →
STAD	All	All	−0.111	<.001	9	view →
KIRC	Female	All	+0.108	<.001	9	view →
HNSC	Male	IV	−0.223	<.001	8	view →
UCEC	All	All	−0.197	<.001	8	view →
LUSC	Male	II,III,IV	−0.179	<.001	8	view →
LIHC	Male	All	−0.131	<.001	8	view →
LUAD	Male	II,III,IV	−0.125	<.001	8	view →
BLCA	Female	III,IV	−0.142	<.001	7	view →
KIRP	Male	II,III,IV	−0.123	<.001	7	view →
CHOL	All	All	−0.296	<.001	5	view →

Pink = more active in tumor, green = less active in tumor. Showing the 12 strongest of 16 lineages.

GO:0033603–THCA

Open the THCA breakdown →