Positive regulation of dopamine secretion

Across TCGA cell cohorts, RNA activity of the Positive regulation of dopamine secretion pathway is significantly associated with the RNA expression of multiple genes, with the UPPER_AERODIGESTIVE_TRACT cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are POLR2H, FBXO32, and DAB2, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, POLR2H grouped by Positive regulation of dopamine secretion-low versus -high activity in UPPER_AERODIGESTIVE_TRACT.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UPPER_AERODIGESTIVE_TRACT	POLR2H →	+0.923	+1.471	.001	.002	3	5
LIVER	FBXO32 →	-3.962	-1.947	<.001	<.001	3	5
LARGE_INTESTINE	DAB2 →	-1.790	-0.799	.003	.009	2	5
LUNG_NSCLC_LUAD	COL4A2 →	-2.704	-0.867	.001	.001	3	4
PANCREAS	ZNF214 →	-0.508	-1.153	.003	<.001	3	4
BONE	TNKS2 →	-0.616	-1.616	<.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

POLR2H by Positive regulation of dopamine secretion activity — UPPER_AERODIGESTIVE_TRACT

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