Positive regulation of mammary gland epithelial cell proliferation

Across TCGA patient cohorts, RNA activity of the Positive regulation of mammary gland epithelial cell proliferation pathway is significantly associated with the protein abundance of multiple proteins, with the HNSC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are NCSTN, ZNF687, and BRCA1_S114, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Positive regulation of mammary gland epithelial cell proliferation activity versus NCSTN in HNSC (Pearson r = 0.26).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
HNSC	NCSTN →	+0.165	+0.077	.002	.001	3	7
HNSC	ZNF687 →	+0.298	+0.083	<.001	<.001	3	6
LUAD	BRCA1_S114 →	+0.852	+0.113	<.001	<.001	3	6
LUAD	RPL12_S38 →	+0.896	+0.090	<.001	<.001	3	6
LUAD	TOP2A_S1247 →	+1.124	+0.098	<.001	<.001	3	6
LUAD	BRIX1 →	+0.445	+0.088	<.001	<.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0033601 vs NCSTN — HNSC

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