S-adenosylmethionine cycle

Across TCGA cell cohorts, RNA activity of the S-adenosylmethionine cycle pathway is significantly associated with the RNA expression of multiple genes, with the BREAST cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are GPR176, SSR4, and CDH8, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, GPR176 grouped by S-adenosylmethionine cycle-low versus -high activity in BREAST.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BREAST	GPR176 →	-1.344	-0.837	<.001	<.001	3	4
UPPER_AERODIGESTIVE_TRACT	SSR4 →	-0.863	-1.112	.004	.002	3	4
BLOOD_Myeloma	CDH8 →	-1.872	-0.517	.001	.001	3	3
UPPER_AERODIGESTIVE_TRACT	ACTR5 →	-0.844	-1.215	<.001	<.001	3	3
LUNG_SCLC	POLB →	+1.012	+0.695	.003	.008	3	3
STOMACH	RFC4 →	+0.640	+0.956	.009	.003	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GPR176 by S-adenosylmethionine cycle activity — BREAST

Explore this box plot interactively →