Cholesterol efflux

Across TCGA patient cohorts, RNA activity of the Cholesterol efflux pathway is significantly associated with the protein abundance of multiple proteins, with the BRCA cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are SMCHD1, SRP68, and ALDH2, each associated with the pathway in up to 8 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Cholesterol efflux activity versus SMCHD1 in BRCA (Pearson r = -0.14).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	SMCHD1 →	-0.333	-0.037	<.001	<.001	3	7
BRCA	SRP68 →	-0.260	-0.042	<.001	<.001	3	7
OV	ALDH2 →	+0.707	+0.038	<.001	.003	2	8
OV	PRPF40A →	-0.197	-0.045	<.001	<.001	3	7
BRCA	RBM25 →	-0.232	-0.044	<.001	<.001	3	7
UCEC	CRYL1 →	+0.696	+0.056	<.001	<.001	3	7

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0033344 vs SMCHD1 — BRCA

Explore this scatter interactively →