Cholesterol efflux

Across TCGA patient cohorts, RNA activity of the Cholesterol efflux pathway is significantly associated with the RNA expression of multiple genes, with the COAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are TLR7, GNL3L, and CR1, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Cholesterol efflux activity versus TLR7 in COAD (Pearson r = 0.11).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	TLR7 →	+0.373	+0.137	.008	<.001	3	5
GBM	GNL3L →	-0.212	-0.092	.001	.002	3	5
CCRCC	CR1 →	+0.671	+0.150	.001	<.001	3	5
PDAC	APOE →	+0.753	+0.140	.002	.003	2	5
PDAC	TSPAN3 →	-0.419	-0.113	.002	.003	3	4
COAD	NCF1C →	+0.740	+0.165	<.001	.002	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0033344 vs TLR7 — COAD

Explore this scatter interactively →