Cholesterol efflux

Across TCGA cell cohorts, RNA activity of the Cholesterol efflux pathway is significantly associated with the RNA expression of multiple genes, with the KIDNEY cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are SLC22A4, RPS6KA4, and DRAP1, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, SLC22A4 grouped by Cholesterol efflux-low versus -high activity in KIDNEY.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
KIDNEY	SLC22A4 →	-1.001	-0.766	.001	.005	3	6
LIVER	RPS6KA4 →	-1.704	-1.853	<.001	<.001	3	5
LIVER	DRAP1 →	-1.468	-1.500	.004	.005	2	6
LUNG_SCLC	SHD →	+3.204	+1.459	.004	.001	3	5
CNS	ADM →	-2.524	-1.052	.009	.009	3	5
BREAST	KMT5C →	+0.661	+0.673	.004	.004	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

SLC22A4 by Cholesterol efflux activity — KIDNEY

Explore this box plot interactively →