Cholesterol efflux

Across TCGA cell cohorts, RNA activity of the Cholesterol efflux pathway is significantly associated with the RNA expression of multiple genes, with the LIVER cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are APOE, APOC1, and FOXM1, each associated with the pathway in up to 14 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Cholesterol efflux activity versus APOE in LIVER (Pearson r = 0.79).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LIVER	APOE →	+4.652	+0.219	<.001	<.001	3	14
LIVER	APOC1 →	+4.352	+0.221	<.001	<.001	3	14
CNS	FOXM1 →	-0.706	-0.103	<.001	<.001	3	9
UPPER_AERODIGESTIVE_TRACT	THEMIS2 →	+1.422	+0.124	.004	.002	3	8
SKIN	CCNB2 →	-0.788	-0.118	.001	.009	3	8
BLOOD_Leukemia	SMIM1 →	+1.941	+0.068	<.001	<.001	3	8

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0033344 vs APOE — LIVER

Explore this scatter interactively →