Cholesterol efflux

Across TCGA cell cohorts, RNA activity of the Cholesterol efflux pathway is significantly associated with the RNA expression of multiple genes, with the OESOPHAGUS cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ZCCHC3, LMO1, and RPS2, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Cholesterol efflux activity versus ZCCHC3 in OESOPHAGUS (Pearson r = -0.46).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OESOPHAGUS	ZCCHC3 →	-0.807	-0.591	<.001	.004	3	3
BLOOD_Lymphoma	LMO1 →	-0.041	-0.764	<.001	<.001	2	4
STOMACH	RPS2 →	-1.144	-0.326	<.001	<.001	3	3
STOMACH	YDJC →	-0.855	-0.255	<.001	<.001	3	3
STOMACH	METTL27 →	-2.059	-0.284	.001	.001	3	3
STOMACH	CFLAR →	+2.135	+0.279	<.001	.004	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0033344 vs ZCCHC3 — OESOPHAGUS

Explore this scatter interactively →