Response to vitamin D

Across TCGA patient cohorts, RNA activity of the Response to vitamin D pathway is significantly associated with the RNA expression of multiple genes, with the HNSC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are SPP1, LOXL2, and FN1, each associated with the pathway in up to 8 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Response to vitamin D activity versus SPP1 in HNSC (Pearson r = 0.30).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
HNSC	SPP1 →	+2.069	+0.624	.002	.003	3	8
BRCA	LOXL2 →	+0.923	+0.450	<.001	<.001	3	7
GBM	FN1 →	+1.073	+0.213	<.001	.002	3	6
CCRCC	TGFBI →	+1.607	+0.333	<.001	<.001	3	6
BRCA	CALU →	+0.567	+0.298	<.001	.003	3	6
LUAD	SPOCK1 →	+0.907	+0.477	<.001	<.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0033280 vs SPP1 — HNSC

Explore this scatter interactively →