Regulation of nuclear cell cycle DNA replication

Across TCGA patient cohorts, RNA activity of the Regulation of nuclear cell cycle DNA replication pathway is significantly associated with the protein abundance of multiple proteins, with the LUAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are BAZ1B_S349, SMC2, and SMC4, each associated with the pathway in up to 10 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of nuclear cell cycle DNA replication activity versus BAZ1B_S349 in LUAD (Pearson r = 0.60).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUAD	BAZ1B_S349 →	+1.434	+0.100	<.001	<.001	3	10
GBM	SMC2 →	+0.632	+0.079	<.001	<.001	3	9
GBM	SMC4 →	+0.619	+0.079	<.001	<.001	3	9
LUAD	TERF2IP_S36 →	+0.932	+0.051	<.001	<.001	3	9
BRCA	LIG1 →	+0.539	+0.052	<.001	<.001	3	9
UCEC	TOP2A →	+1.002	+0.112	<.001	<.001	3	9

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0033262 vs BAZ1B_S349 — LUAD

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