Positive regulation of amine metabolic process

Across TCGA patient cohorts, RNA activity of the Positive regulation of amine metabolic process pathway is significantly associated with the RNA expression of multiple genes, with the BRCA cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ABAT, PDK1, and ERO1A, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Positive regulation of amine metabolic process activity versus ABAT in BRCA (Pearson r = 0.59).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	ABAT →	+1.176	+0.202	<.001	<.001	3	7
BRCA	PDK1 →	-0.774	-0.202	<.001	<.001	3	6
PDAC	ERO1A →	-0.787	-0.092	<.001	.005	3	6
COAD	CTTNBP2 →	+1.048	+0.120	<.001	.003	3	6
COAD	ABCB1 →	+1.175	+0.139	.006	.006	3	6
UCEC	CENPI →	-0.675	-0.143	.001	<.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0033240 vs ABAT — BRCA

Explore this scatter interactively →