Regulation of amine metabolic process

Across TCGA patient cohorts, RNA activity of the Regulation of amine metabolic process pathway is significantly associated with the protein abundance of multiple proteins, with the GBM cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are LSP1, ARHGAP30, and PLCB2, each associated with the pathway in up to 9 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of amine metabolic process activity versus LSP1 in GBM (Pearson r = 0.23).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	LSP1 →	+0.697	+0.093	<.001	<.001	3	9
GBM	ARHGAP30 →	+0.627	+0.083	<.001	<.001	3	8
GBM	PLCB2 →	+0.545	+0.087	<.001	<.001	3	8
GBM	WAS →	+0.643	+0.101	<.001	<.001	3	8
GBM	BTK →	+0.531	+0.099	<.001	<.001	3	8
LSCC	PLEKHO2_T311 →	+0.554	+0.107	<.001	<.001	3	8

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0033238 vs LSP1 — GBM

Explore this scatter interactively →