Response to vitamin E

Across TCGA cell cohorts, RNA activity of the Response to vitamin E pathway is significantly associated with the RNA expression of multiple genes, with the PANCREAS cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are FZR1, LZTS2, and SHPK, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Response to vitamin E activity versus FZR1 in PANCREAS (Pearson r = -0.54).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PANCREAS	FZR1 →	-0.415	-0.762	.006	.004	3	5
BLOOD_Leukemia	LZTS2 →	+1.058	+0.315	<.001	.005	3	4
PANCREAS	SHPK →	-0.683	-1.075	<.001	.003	3	4
BLOOD_Leukemia	C12orf75 →	-2.295	-0.300	.002	.009	3	3
BLOOD_Leukemia	ZNF737 →	-1.576	-0.172	.002	.003	3	3
BLOOD_Leukemia	C2orf15 →	-0.657	-0.331	<.001	.005	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0033197 vs FZR1 — PANCREAS

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