Positive regulation of mast cell activation

Across TCGA patient cohorts, RNA activity of the Positive regulation of mast cell activation pathway is significantly associated with the RNA expression of multiple genes, with the BRCA cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are NOP14, SRRT, and STX1A, each associated with the pathway in up to 3 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Positive regulation of mast cell activation activity versus NOP14 in BRCA (Pearson r = -0.19).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	NOP14 →	-0.327	-0.827	.003	<.001	3	3
PDAC	SRRT →	-0.250	-0.636	.001	.001	3	3
LUAD	STX1A →	-0.614	-0.451	.002	.001	3	3
LUAD	SMARCA4 →	-0.471	-0.556	<.001	<.001	3	3
LUAD	DCAF15 →	-0.336	-0.442	.009	.006	3	3
LUAD	GAB2 →	+0.336	+0.373	<.001	.002	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0033005 vs NOP14 — BRCA

Explore this scatter interactively →