Positive regulation of mast cell activation

Across TCGA pan-cancer cohorts, RNA activity of the Positive regulation of mast cell activation pathway is associated with patient survival in 25 of 34 cancer lineages. Pathway activity is summarized from the expression of its 21 member genes.

The strongest signal is observed in small cell lung cancer (SCLC), where higher Positive regulation of mast cell activation pathway activity is associated with better overall survival. In most high-consensus cancer types, elevated pathway activity shows an unfavorable survival association, although some cancer types, such as SCLC and STAD, show the opposite pattern, with higher activity associated with better survival.

SCLC, UCEC, and ACC are the cancer lineages in which this pathway most reproducibly stratifies patient survival.

Pathway-activity survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 represent the survival AUCs for the high- and low-pathway-activity groups, respectively. The group with the lower AUC is interpreted as having poorer survival. The reported p-values are derived from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
SCLC	OS	Tertile	All	0.809	0.441	<.001	105	view →
UCEC	OS	Median	All	0.895	0.954	<.001	48	view →
ACC	DFS	Median	IV	0.048	0.380	<.001	31	view →
STAD	OS	Quartile	IV	0.551	0.166	.006	29	view →
BRCA	DFS	Quartile	All	0.926	0.957	.015	29	view →
LIHC	DFS	Median	II,III,IV	0.211	0.409	.001	27	view →
MESO	OS	Median	All	0.428	0.647	.006	24	view →
LUAD	DFS	Tertile	IV	0.335	0.777	.016	18	view →
HNSC	OS	Quartile	All	0.627	0.844	.009	16	view →
COAD	DFS	Quartile	All	0.739	0.853	.010	15	view →
READ	DFS	Quartile	II,III,IV	0.264	0.863	.002	13	view →
UCS	DFS	Tertile	IV	0.978	0.490	.024	12	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 25 lineages.

GO:0033005–SCLC (OS)

Open the SCLC breakdown →